How Parkinson’s Disease Affect Functionality Of The Brain
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Looking at the health topic Parkinson’s disease and how it affect the functionality of the brain. First you may ask what is Parkinson disease?
Parkinson is a disease which involves the malfunction and death of nerve cells in the brain. But according to new research Parkinson disease do originate in the gut while extending to the cells of the brain.
And based on united state stastic, Parkinson’s disease is a progressive movement disorder, affecting as many as 1 million people in the United States and 7 million to 10 million people worldwide, according to the Parkinson’s Disease Foundation.
The new study prove that a protein in nerve cells that becomes corrupted and then forms clumps in the brains of people with Parkinson’s can also be found in cells that line the small intestine which include mice and human cells based on the research .
The finding supports the idea that this protein first becomes altered in the gut and then travels to the brain, where it causes the symptoms of Parkinson’s disease.
The protein, called alpha-synuclein, is abundant in the brain . And in healthy nerve cells, it dissolves in the fluid within the cell. But in Parkinson’s patients, alpha-synuclein folds abnormally. The misfolded protein can then spread through the nervous system to the brain as a prion, or infectious protein. In the brain, the misfolded protein molecules stick to each other and clump up, damaging neurons.
Research published this year looked at people who had ulcers and who underwent a surgery that removed the base of the vagus nerve, which connects the brain stem to the abdomen. These patients had a 40 percent lower risk of developing Parkinson’s later in life compared with people who didn’t have their vagus nerve removed. Both findings suggested the prion may originate in the gut.
Previous research has shown that people exposed to certain pesticides and bacteria are more likely to get Parkinson’s.